Dr. Samie Jaffrey, the Greenberg-Starr Professor in the Department of Pharmacology at Weill Cornell Medicine, has received a five-year, $5.5 million NIH Director’s Transformative Research Award for the comprehensive study of how messenger RNAs are regulated in cells by small molecules called metabolites.
The NIH Director’s Transformative Research Awards, part of the Common Fund’s High-Risk, High-Reward Research, fund bold and innovative projects that have the potential to transform one or more fields of biomedical research. Only six such awards were issued in 2026. Dr. Jaffrey and his team are known both for their development of tools for studying RNA molecules and for their use of such tools to make important discoveries. Their recent work suggests that metabolites—relatively simple molecules involved in cell metabolic processes—represent a previously hidden layer of mRNA regulation in higher organisms. With the new NIH award, the scientists will comprehensively map and characterize metabolite-RNA interactions. Their aim is to open up this realm of biology for basic research and the development of novel disease treatments.