A team of Weill Cornell Medicine investigators has developed a computer model that will help scientists more efficiently develop protein-destroying therapies, a newer type of treatment that is particularly promising for cancer. The study was published July 13 in Nature Communications.
Most drugs use a small molecule to render disease-causing proteins harmless, but protein-degrader therapies aim to destroy the target protein altogether. Eliminating proteins, for example, those with cancer-causing mutations, or proteins produced in harmful excess quantities may offer advantages over disabling a protein. The new model could potentially shave years off the process of developing a new protein degrader therapy.

Dr. Olivier Elemento