News and Events

Programs and providers of Obstetrics and Gynecology at Weill Cornell Medicine are often the focus of news stories and features appearing in major national media. We invite you to review some stories that typify the breakthrough accomplishments of our remarkable team and highlight the impact our care has had on patient’s lives.

Light-Activated Opioid Painkiller May Work Without Dangerous Side Effects

silhouette of a woman taking a pill

Opioid painkillers are some of the strongest analgesic medicines, but they are also the riskiest owing to a range of side effects, including addiction. An experimental opioid painkiller designed to be reversibly switched on and off with different light frequencies, keeping its action local and out of the brain, may eliminate the dangerous side effects of current opioids, according to a study led by Weill Cornell Medicine and University of Pennsylvania investigators. The findings herald a broad new approach for targeting medicines more precisely and effectively.

The investigators, whose results are published Oct. 15 in Cell, engineered a morphine-based compound called AM-3 that changes its shape in response to light in a certain frequency range. This conformational change alters AM-3’s degree of engagement with the mu-opioid receptor, the principal target of opioid painkiller drugs. The researchers showed that with this light-switching or “photopharmacology” approach they could activate AM-3’s painkilling effect only where needed, allowing substantial pain relief without side effects in multiple preclinical pain models, including cancer pain models.

Gale and Ira Drukier Prize in Children’s Health Research Awarded to Harvard Pediatric Hematologist-Oncologist

The Drukiers, honorees and leadership

Dr. Robbie Majzner, an esteemed physician-scientist whose research focuses on children with intractable cancers, has been awarded the 11th annual Gale and Ira Drukier Prize in Children’s Health Research by Weill Cornell Medicine.

The Drukier Prize recognizes an early-career pediatrician whose research contributions have the potential to significantly improve the health and well-being of children and adolescents. Dr. Majzner is an associate professor of pediatrics at Harvard Medical School and a pediatric hematologist-oncologist at Harvard-affiliated Dana-Farber Cancer Institute/Boston Children’s Hospital.

He is being recognized for his research efforts to design better CAR T-cells, understand the cancer targets those cells attack and test the resulting therapies, particularly in children with solid tumors and cancers that develop resistance to existing treatments.

Dr. Majzner’s lab studies how CAR T-cells—genetically engineered immune cells programmed to recognize and destroy cancer cells—receive and transmit signals once they encounter a cancer cell. This understanding of how the engineered immune cells function has allowed his lab to reimagine how they are designed and deployed.

Stigma in Parents of Children with Mental Health Problems

photo of child between parents, holding hands

Parents of children with mental health problems may experience stigma when the ideals that matter most to being considered a “good parent” are perceived as not being met, according to preliminary research led by Weill Cornell Medicine, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian investigators. Discussions with a group of these parents are helping inform new approaches to supporting parents and restoring more positive feelings about parenting skills when faced with a child’s mental health struggles.

The study, published online on Oct. 6 as a special article in Psychiatric Services, identified qualities that may contribute to parents feeling more secure and respectable in raising their child, including emotional support, open communication, boundaries, and role modeling. The researchers suggest that supporting parents in fulfilling these qualities can help parents feel less self-blame and stigmatization for their child’s mental health problems.

headshot of a man

Dr. Tim Becker